|
KMID : 0359320130530030159
|
|
Korean Journal of Veterinary Research
2013 Volume.53 No. 3 p.159 ~ p.162
|
|
|
Immunohistochemical localization of galectin-3 in the brain with Theiler’s murine encephalomyelitis virus (DA strain) infection
|
|
Shin Tae-Kyun
Carrillo-Salinas Francisco J.
Martinez Ana Feliu
Mecha Miriam
Guaza Carmen
|
|
|
Abstract
|
|
|
|
Galectin-3 is a β-galactoside-binding lectin that plays a role in neuroinflammation through cell migration, proliferation, and apoptosis. In the present study, regulation of galectin-3 was examined in the brain of mice infected with the Daniel strain of Theiler’s murine encephalomyelitis virus (TMEV) at days 7 and 81 post-infection by immunohistochemistry. Immunohistochemistry revealed that galectin-3 was mainly localized in ionized calcium-binding adapter 1-positive macrophages/activated microglia, but not in Iba-1-positive ramified microglia. Galectin-3 was also weakly detected in some astrocytes in the same encephalitic lesions, but not in neurons and oligodendrocytes. Collectively, the present findings suggest that galectin-3, mainly produced by activated microglia/macrophages, may be involved in the pathogenesis of virus induced acute inflammation in the early stage as well as the chronic demyelinating lesions in Daniel strain of TMEV induced demyelination model.
|
|
|
KEYWORD
|
|
|
encephalomyelitis, galectin-3, macrophages, microglia, Theiler’s murine encephalomyelitis virus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|